管理No.AC20180207-01(Original work)Effect of the rind portion in Hassaku extracts on the pharmacokinetics of primidone

管理No AC20180207-01
受付日 2018年1月30日
受理日 2018年2月7日
論文の種類 Original work(原著)
著者名 Makoto NAGAI1, Kazuhiro INAGAKI2

Department of Medical Technology, School of Health Sciences, Gifu University of Medical Science1

Department of Pharmacy, Mejou University2

論文(電子版) No.AC20180207-01
キーワード Hassaku, Primidone, CYP3A, Pharmacokinetic
掲載 医療看護環境学
Medical Nursing Environment Science
Vol.1, No.1, Page.26-29, (26-29)

Summary

We investigated the effects of Hassaku extracts on the pharmacokinetics and dynamics of primidone.  After pretreatment with water or Hassaku extracts, Primidone was administered and its pharmacokinetics and pharmacodynamics were measured. After oral administration, pretreatment with Hassaku extracts did not increase the peak plasma concentration (C max), and there was no change in the area under the plasma concentration-time curve (AUC) of Primidone. Pretreatment with Hassaku extracts doesn’t increase bioavailability and changes in the pharmacodynamics of Primidone.

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