管理No.AC20180207-02(Original work)Interaction of lime and hassaku orange components with rat and human P450 CYP3A

管理No AC20180207-02
受付日 2018年1月31日
受理日 2018年2月7日
論文の種類 Original work(原著)
著者名 Makoto NAGAI1, Kazuhiro INAGAKI2

Department of Medical Technology, School of Health Sciences, Gifu University of Medical Science1

Department of Pharmacy, Mejou University2

論文(電子版) No.AC20180207-02
キーワード Hassaku orange, lime, inhibitor, CYP3A activity
掲載 医療看護環境学
Medical Nursing Environment Science
Vol.1, No.1, Page.30-34, (30-34)

Summary

We investigated the effects of seedcase extracts from hassaku orange and lime on rat and human CYP3A activity. The seedcases of grapefruit and lime showed the most potent inhibition. The seedcases of hassaku orange caused weaker inhibition of human microsomal CYP3A activity than the seedcases of grapefruit and lime. It is presumed that the inhibitors in the seedcases of hassaku orange are different substances from the inhibitors of grapefruit and lime. Therefore, evaluation of CYP3A activity in rats gives results close to that of human CYP3A activity. Final CYP3A activity inhibition assessment should be performed on human microsomes.

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